2012 Fiscal Year Final Research Report
Study on the application to oral cancer treatment drug of Ni2+ion
| Project/Area Number |
23890218
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 金属イオン / 癌 / シグナル伝達 |
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| Research Abstract |
IL-8 plays an important role by put the progression of malignant tumors. Ni compounds have been recognized as a carcinogen, but there are many unclear points in the context of IL-8. We studied the effect of Ni2 + ions for the secretion of IL-8 spontaneous using oral squamous cell carcinoma cell lines, As a results, Ni ions inhibited IL-8 secretion in a dose-and time-dependent manner. It indicated that the cluster of histidine at the N-terminal part of the molecule of p50 is required for binding of the Ni ions.
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