2012 Fiscal Year Final Research Report
Epigenetic regulation of serotonin transporter in bipolar disorder
| Project/Area Number |
23890250
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Women's Medical University (2012)
The Institute of Physical and Chemical Research (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 双極性障害 / 一卵性双生児 / セロトニントランスポーター / DNA メチル化 / 死後脳 |
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| Research Abstract |
We performed promoter-wide DNA methylation analysis of lymphoblastoid cell lines (LCLs) derived from two pairs of monozygotic twins discordant for bipolar disorder (BD). We found distinct difference of DNA methylation in SLC6A4 encoding serotonin transporter (HTT), which is a target of antidepressants and is one of the strongest candidate molecules of mood disorder. Promoter hypermethylation of SLC6A4 in LCLs of BD patients was confirmed in a case-control analysis. DNA methylation of SLC6A4 was significantly correlated with its mRNA expression level in individuals with the S/S genotype of serotonin transporter-linked promoter region (HTTLPR), and mRNA expression level was lower in BD patients carrying the S/S genotype. DNA methylation of the same site was also higher in the postmortem brains of BD patients.
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Research Products
(38 results)
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[Journal Article] Genome-wide DNA methylation and gene expression analyses of monozygotic twins discordant for intelligence levels2012
Author(s)
Yu CC, Furukawa M, Kobayashi K, Shikishima C, Cha PC, Sese J, Sugawara H, Iwamoto K, Kato T, Ando J, Toda T
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Journal Title
PLoS ONE
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins2011
Author(s)
Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno A, Adati N, Kusuni I, Okazaki Y, Ishigooka J, Kojima T, Kato T
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Journal Title
Transl Psychiatry
Volume: 1
Pages: e24
DOI
Peer Reviewed
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[Presentation] Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins2012
Author(s)
Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno A, Adati N, Kusuni I, Okazaki Y, Ishigooka J, Kojima T, Kato T
Organizer
5th Biennial Conference of ISBD
Place of Presentation
Istanbul
Year and Date
20120314-17
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[Presentation] Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins
Author(s)
Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno A, Adati N, Kusuni I, Okazaki Y, Ishigooka J, Kojima T, Kato T
Organizer
2EABF
Place of Presentation
Fukuoka
Year and Date
00000907-08
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[Presentation] Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins
Author(s)
Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno A, Adati N, Kusuni I, Okazaki Y, Ishigooka J, Kojima T, Kato T
Organizer
XXVIIIth CINP Congress
Place of Presentation
Stockholm
Year and Date
00000603-07
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