Novel Cardiac Workload Evaluation System Based on Echocardiography and MRI Flow Visualization Method and its Application to the Cardiovascular Disease in Elderly Patients

2012 Fiscal Year Final Research Report

• Project/Area Number: 23890259
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Kitasato University
• Principal Investigator: ITATANI Keiichi 北里大学, 医学部, 准教授 (70458777)
• Project Period (FY): 2011 – 2012
• Keywords: 血流可視化 / 心負荷 / 大動脈弁閉鎖不全症 / 心臓超音波 / 心臓 MRI / 心機能評価

Research Abstract

For the development of the cardiac workload evaluation system in elderly patients based on the echocardiography and cardiac MRI, we at first, developed blood flow visualization method using echocardiography and cardiac MRI. Echocardiography VFM (vector flow mapping) has been established and MRI blood flow visualization software has been also created using PC (phase contrast) MRI. From the visualized blood flow velocity vector field, we developed a system to calculate flow energy loss. Then we applied these systems to aortic valve regurgitation cases, and 3 cases were evaluated with echocardiography, and other 3 cases were evaluated with MRI. From the results, flow energy loss caused by the regurgitation jet was proven to be closely related to the flow collision with transmitral flow in the left ventricle.

Research Products

• [Journal Article] Strategies for the creation and maintenance of reconstructed arteriovenous fistulas using the forearm basilic vein (2013)
  • Author(s): Kumano S, Itatani K, Shiota J, Gojo S, Izumi N, Kasahara H, Homma Y, Tagawa H
  • Journal Title: Ther Apher Dial
  • Peer Reviewed
• [Journal Article] Surgical strategy for severe aortic hypoplasia and aortic stenosis with ventricular septal defect and normal left ventricle (2013)
  • Author(s): Tomoyasu T, Oka N, Miyamoto T, Kitamura T, Itatani K, Inoue N, Ishii M, Miyaji K
  • Journal Title: Pediatr Cardiol
  • Peer Reviewed
• [Journal Article] Intraventricular flow velocity vector visualization based on the continuity equation and measurements of vorticity and wall shear stress (2013)
  • Author(s): Itatani K, Okada T, Uejima T, Tanaka T, Ono M, Miyaji K, Takenaka K
  • Journal Title: Jpn J Appl Physic
  • Peer Reviewed
• [Journal Article] Subacute presentation of right ventricular perforation after pacemaker implantation (2013)
  • Author(s): Koyama S, Itatani K, Kyo S, Aoyama R, Ishiyama T, Harada K, Ono M
  • Journal Title: Ann Thracic Cardiovasc Surg Volume: 19(1) Pages: 73-5
  • Peer Reviewed
• [Journal Article] Aortic valve replacement and concomitant coronary artery bypass grafting in a patient with infective endocarditis and anomalous origin of the right coronary artery from the opposite sinus of Valsalva (2012)
  • Author(s): Koyama S, Itatani K, Kyo S, Aoyama R, Tubokou Y, Fujimoto H, Harada K
  • Journal Title: Ann Thorac Cardiovasc Surg
  • Peer Reviewed
• [Journal Article] The lower limit of the pulmonary artery index for the extracardiac Fontan circulation (2012)
  • Author(s): Itatani K, Miyaji K. Reply to the editor
  • Journal Title: J Thorac Cardiovasc Surg Volume: 143(4) Pages: 990
  • Peer Reviewed
• [Journal Article] 先天性大動脈疾患の血流シミュレーションにおける反射波応答を加味した境界条件の検討 (2012)
  • Author(s): 宮崎翔平, 板谷慶一, 劉 金龍, 銭 逸, 宮地 鑑, 横田 元, 小野 稔, 梅津光生
  • Journal Title: 日本機械学会 バイオエンジニアリング講演会
• [Journal Article] Half-turned truncal switch operation for transposition of great arteries with ventricular septal defect and pulmonary regurgitation (2011)
  • Author(s): Myaji K, Itatani K, Inoue N, Ishii M
  • Journal Title: Interact Cardiovasc Thorac Surg Volume: 13(2) Pages: 217-9
  • Peer Reviewed
• [Journal Article] Left ventricular assist device support with a centrifugal pump for 2 months in a 5-kg child (2011)
  • Author(s): Inoue T, Nishimura T, Murakami A, Itatani K, Takaoka T, Kitahori K, Umeki A, Takezoe T, Kashiwa K, Kyo S, Ono M
  • Journal Title: J Artif Organs
  • Peer Reviewed
• [Journal Article] 先天性大動脈疾患の血流シミュレーションにおける境界条件と乱流モデルの検討 (2011)
  • Author(s): 宮崎翔平, 板谷慶一, 劉 金龍, 銭 逸, 宮地 鑑, 横田 元, 小野 稔, 梅津光生
  • Journal Title: 日本流体力学会数値流体シンポジウム
• [Journal Article] The effectiveness of high-flow regional cerebral perfusion in Norwood stage I palliation (2011)
  • Author(s): Miyaji K, Miyamoto T, Kohira S, Yoshii T, Itatani K, Inoue N
  • Journal Title: Eur J Cardiothorac Surg Volume: 40(5) Pages: 1215-20
  • Peer Reviewed
• [Journal Article] The lower limit of the pulmonary artery index for the extracardiac Fontan circulation (2011)
  • Author(s): Itatani K, Miyaji K, Nakahata Y, Ohara K, Takamoto S, Ishii M
  • Journal Title: J Thorac Cardiovasc Surg Volume: 142(1) Pages: 127-35
  • Peer Reviewed
• [Journal Article] Influence of surgical arch reconstruction methods on single ventricle workload in the Norwood procedure (2011)
  • Author(s): Itatani K, ,, , Miyaji K, Qian Y, Liu JL, Miyakoshi T, Murakami A, Ono M, Umezu M
  • Journal Title: J Thorac Cardiovasc Surg Volume: 144 Pages: 130-8
  • Peer Reviewed
• [Journal Article] Image-based computational hemodynamics of distal aortic arch recoarctation following the Norwood procedure (2011)
  • Author(s): Liu JL, Qian Y, Itatani K, Murakami A, Shiurba R, Miyakoshi T, Miyaji K, Umezu M
  • Journal Title: BMEI Pages: 318-23
  • Peer Reviewed
• [Journal Article] An approach of computational hemodynamics for cardiovascular flow simulation (2011)
  • Author(s): Liu JL, Qian Y, Itatani K, Miyakoshi T, Murakami A, Ono M, Shiurba R, Miyaji K, Umezu M
  • Journal Title: AJK2011-03057 Pages: 1449-1456
  • Peer Reviewed
• [Presentation] ベクトルを用いて心臓血管内の血流を"診る"VFM (Vector Flow Mapping) (2013)
  • Author(s): 板谷慶一
  • Organizer: 第24回日本心エコー図学会
  • Place of Presentation: 第24回日本心
  • Year and Date: 20130425-27
• [Presentation] VFM (Vector Flow Mapping)がもたらす循環生理学と循環器診療への新たな視点 (2013)
  • Author(s): 板谷慶一
  • Organizer: 第24回日本心エコー図学会
  • Place of Presentation: 東京
  • Year and Date: 20130425-27
• [Presentation] Novel blood flow visualization technique with echocardiography and its application to the cardiovascular surgery (2013)
  • Author(s): Keiichi Itatan
  • Organizer: Asian Cardiovascular and Thoracic Surgery
  • Place of Presentation: 神戸
  • Year and Date: 20130404-07
• [Presentation] A novel approach to aortic insufficiency based on quantitative cardiac workload estimation from visualized blood flow with MRI and echocardiography (2013)
  • Author(s): Keiichi Itatani
  • Organizer: Asian Cardiovascular and Thoracic Surgery 2013
  • Place of Presentation: 神戸
  • Year and Date: 20130400-0700
• [Presentation] 血流速度ベクトルを測って活かす (2013)
  • Author(s): 板谷慶一
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-15
• [Presentation] 血行動態から見た多肢病変における至適バイパスグラフトデザイン (2012)
  • Author(s): 小山紗千, 板谷慶一, 山本匡, 宮崎翔平, 朴栄光, 小野稔, 梅津光生
  • Organizer: 第65回日本胸部外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 20121017-20
• [Presentation] カラードップラで満足していますか (2012)
  • Author(s): 板谷慶一
  • Organizer: 第23回 日本心エコー図学会 イブニングセミナー
  • Place of Presentation: 大阪
  • Year and Date: 20120419-21
• [Presentation] 先天性大動脈疾患の血流シミュレーションにおける反射波応答を加味した境界条件の検討 (2012)
  • Author(s): 宮崎翔平, 板谷慶一, 劉金龍, 銭逸, 宮地鑑, 横田元, 小野稔, 梅津光生
  • Organizer: 日本機械学会バイオエンジニアリング講演会
  • Place of Presentation: 大阪
  • Year and Date: 20120107-08
• [Presentation] 渦を測ってみよう VFM (2012)
  • Author(s): 板谷慶一
  • Organizer: 日本心エコー図学会秋の講習会
  • Place of Presentation: 東京
  • Year and Date: 2012-10-07
• [Presentation] ベクトルを用いて心臓血管内血流を診る:超音波による新たな血流可視化ソフトウェアVFM(Vector Flow Mapping) (2012)
  • Author(s): 板谷慶一
  • Organizer: 第3回 相模心臓血管外科懇話会
  • Place of Presentation: 神奈川
  • Year and Date: 2012-09-22
• [Presentation] 左冠動脈多肢病変における血流動態から見た至適なバイパスグラフトデザイン (2012)
  • Author(s): 小山紗千, 板谷慶一, 山本匡, 宮崎翔平, 小川大輔, 朴栄光, 小野稔, 梅津光生
  • Organizer: 第17回日本冠動脈外科学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-07-12
• [Presentation] 心臓血管内血流をベクトルで求める方法について (2012)
  • Author(s): 板谷慶一
  • Organizer: 第76回 日本循環器学会ランチョンセミナー
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-16
• [Presentation] Quantitative evaluation of the hemodynamics in Fontan circulation (2012)
  • Author(s): 本田崇, 板谷慶一, 木村純人, 中畑弥生, 宮地鑑, 石井正浩
  • Organizer: 76回日本循環器学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-16
• [Presentation] 新たなVector Flow Mapping と臨床応用の可能性 (2011)
  • Author(s): 板谷慶一
  • Organizer: 第84回 日本超音波医学会 シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-05-27
• [Patent(Industrial Property Rights)] 磁気共鳴イメージング装置、画像処理装置、画像診断装置、画像解析装置、MRI画像作成方法およびプログラム (2013)
  • Inventor(s): 板谷慶一 宮地鑑 宮崎翔平 高橋哲彦
  • Industrial Property Rights Holder: 北里大学、株式会社日立メディコ
  • Industrial Property Number: 2013-104972
  • Filing Date: 2013-05-08
• [Patent(Industrial Property Rights)] 血流可視化診断装置 (2012)
  • Inventor(s): 板谷慶一 小野稔
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Industrial Property Number: PCT / JP2012/ 063484
  • Filing Date: 2012-05-25
  • Overseas
• [Patent(Industrial Property Rights)] 流体流速検出装置及びプログラム (2012)
  • Inventor(s): 板谷慶一 小野稔 岡田孝
  • Industrial Property Rights Holder: 国立大学法人東京大学、日立アロカメディカル株式会社
  • Industrial Property Number: 2012-060973
  • Filing Date: 2012-03-16
• [Patent(Industrial Property Rights)] 血流可視化診断装置及びプログラム (2011)
  • Inventor(s): 板谷慶一 小野稔
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Industrial Property Number: 2011-258191
  • Filing Date: 2011-11-28