Exploring new risk factors for post-myocardial infarction fatal events

2023 Fiscal Year Research-status Report

• Project/Area Number: 23K07573
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: 成瀬 代士久 浜松医科大学, 医学部, 助教 (80814417)
• Co-Investigator(Kenkyū-buntansha): 坂本 篤志 浜松医科大学, 医学部, 助教 (80940436)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Keywords: 急性心筋梗塞 / 致死性不整脈 / 着用型除細動器

Outline of Annual Research Achievements

2023年3月31日現在で363例を登録した。
このうち206例登録時点の退院時までのデータについて第88回日本循環器学会学術集会で発表した（Actual status of wearable cardioverter defibrillator use in patients with acute myocardial infarction -A report from SING AMI registry-）
この発表の結果と結論は以下の通りである。
Results: Among 206 patients with AMI (ages 70.9 ± 12.8 years, male 74.8 percent), 13 (6.3%) had WCD indication. Although physicians considered WCD indication for 9 patients, misidentified indication in 7: VF occurrence within 48h after AMI onset in 2, NSVT in 2, and unknown reason in 3. Of 20 patients with WCD indication or misidentified indication, 19 patients did not receive informed consent about WCD because physicians missed indication in 11, poor general condition in 2, expected poor compliance in 2, and ICD implantation before discharge in 1, unknown reason in 4. One patient disagreed with taking WCD because of the high cost and resistance to WCD. As a result, WCD was prescribed in no patients.
Conclusions: Data from the SING AMI registry showed that using WCD after AMI was underused although WCD was indicated in 6% of patients with AMI undergoing primary PCI. Rate of misidentification for WCD indication was not rare (8.7%), even at facilities with capable of WCD.

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

おおむね予想通りのペースで症例登録が出来ている

Strategy for Future Research Activity

参加施設の増加を検討している。症例登録を進め、それぞれの症例で心筋梗塞発症後2年間のFollow upを行う。そのFollow upデータも含めて論文化を行う予定である。

Causes of Carryover

血液検体の解析が次年度にずれ込んだため。

Research Products

• [Presentation] Actual status of wearable cardioverter defibrillator use in patients with acute myocardial infarction -A report from SING AMI registry- (2024)
  • Author(s): Terumori Satoh, Yoshihisa Naruse, Yuichi Suzuki, Yusuke Mizuno, Ryota Sato, Satoshi Mogi, Nobuyuki Wakahara, Hirofumi Sugiyama, Masayoshi Asai, Keita Kodama, Kohei Sawasaki, Yoshitaka Kawaguchi, and Yuichiro Maekawa
  • Organizer: 第88回日本循環器学会学術集会