2023 Fiscal Year Annual Research Report
The potential role and mechanism of mitophagy in maintaining the biological characteristics of cancer stem cells
| Project/Area Number |
23K14598
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| Research Institution | Nagasaki University |
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Principal Investigator |
YAN Chen 長崎大学, 原爆後障害医療研究所, 講師 (70968396)
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| Project Period (FY) |
2023-04-01 – 2024-03-31
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| Keywords | Cancer stem cells / Mitophagy / Cancer |
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| Outline of Annual Research Achievements |
To investigate the potential role of mitophagy in maintaining the biological characteristics of cancer stem cells, human colorectal cancer cells (HCT116) were used in experiments. We found that Mdivi-1, a pharmacological mitophagy inhibitor, slightly decreased the clonogenic formation ability of HCT116 cells. Interestingly, doxorubicin treatment of HCT116 cells for 7 days upregulated several mitophagy-related genes and increased mitophagy activity, but inversely decreased the expression of cancer stem cell markers (Sox2 and c-myc). Further studies are warranted to elucidate the precise role and relevant mechanism of mitophagy in cancer stem cells.
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