2023 Fiscal Year Research-status Report
The development of MRI-based non-invasive biomarkers to investigate the effect of vascular risk factors on the glymphatic system
| Project/Area Number |
23K14927
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
アンディカ クリスティーナ 順天堂大学, 健康データサイエンス学部, 講師 (00965460)
|
|---|
| Project Period (FY) |
2023-04-01 – 2026-03-31
|
| Keywords | Glymphatic system / Metabolic sydrome / Marijuana / DTI-ALPS / Free water imaging |
|---|
| Outline of Annual Research Achievements |
In the present research project, diffusion magnetic resonance imaging-based measures were applied to evaluate the glymphatic system function. The glymphatic system is a glial-based perivascular network that promotes brain metabolic waste clearance.
Our findings were as follows:
1. Glymphatic system alterations in older adults with metabolic sydrome: we showed reduced glymphatic clearance function in older adults with metabolic syndrome, possibly due to the adverse effects of vascular risk factors on the glymphatic system. Our findings also indicate associations between reduced glymphatic clearance function and elevated diastolic blood pressure, hyperglycemia, smoking habit, and poorer cognitive performance.
2. Glymphatic system alterations in marijuana users: we observed the adverse effects of younger age at first use of marijuana on glymphatic system function, which is associated with impaired working memory and fluid intelligence.
|
| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
As planned, data can be collected in a timely manner, and data analysis and paper writing can also proceed according to schedule.
|
| Strategy for Future Research Activity |
Data analysis is currently underway to evaluate the relationship between impaired glymphatic system function and changes in brain microstructure.
|
| Causes of Carryover |
The budget will be used to pay for purchasing a workstation, as well as covering open access fees, conference participation fees, and English proofreading.
|
Research Products
(2 results)
