2023 Fiscal Year Research-status Report
Development of new biomarkers to predict the therapeutic efficacy and prognosis of systemic chemotherapy for hepatocellular carcinoma
| Project/Area Number |
23K15068
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| Research Institution | Osaka University |
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Principal Investigator |
前阪 和城 大阪大学, 医学部附属病院, 特任助教(常勤) (80974857)
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| Project Period (FY) |
2023-04-01 – 2026-03-31
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| Keywords | 肝細胞癌 |
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| Outline of Annual Research Achievements |
肝細胞癌に対して薬物療法を施行した症例を集積した多施設共同研究Osaka Liver Forum（OLF）への症例登録を継続し、新規薬剤を実施された症例も含めて、前向き観察コホートを800例まで拡大した。
複合免疫療法を実施された症例を対象に得られた臨床情報を用いて、短期的に各薬剤での奏功症例と非奏功症例の比較検討を行い治療効果の予測可能なバイオマーカー候補の探索を実施している。
また、長期のフォローアップを経た症例を対象に治療効果や生命予後に関与する因子の検討を行い論文発表を行った。
Kai M, Hikita H, Kazuki M, et al. Clinical factors associated with the therapeutic efficacy of atezolizumab plus bevacizumab in patients with unresectable hepatocellular carcinoma: A multicenter prospective observational study. PLoS One. 2024 Jan 2;19(1):e0294590.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
症例集積は順調であり、得られたデータから論文発表を行った。
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| Strategy for Future Research Activity |
前向き観察コホートの拡大を継続し、より長期に観察を実施した症例でバイオマーカーの探索を実施する。
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[Journal Article] Clinical factors associated with the therapeutic efficacy of atezolizumab plus bevacizumab in patients with unresectable hepatocellular carcinoma: A multicenter prospective observational study2024
Author(s)
Kai M, Hikita H, Kazuki M, Tahata Y, Shinkai K, Doi A, Ohkawa K, Miyazaki M, Ishida H, Matsumoto K, Nozaki Y, Yakushijin T, Sakamori R, Kaneko A, Iio S, Nawa T, Kakita N, Morishita N, Hiramatsu N, Usui T, Imanaka K, Doi Y, Sakakibara M, Yoshida Y, Oze T, Kodama T, Tatsumi T, Takehara T.
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Journal Title
PLOS ONE
Volume: 19
Pages: e0294590
DOI
Peer Reviewed / Int'l Joint Research
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[Presentation] Clinical factors associated with the therapeutic efficacy of atezolizumab plus bevacizumab in patients with unresectable hepatocellular carcinoma: A multicenter prospective observational study2023
Author(s)
Kazuki Maesaka, Hayato Hikita, Machiko Kai, Yuki Tahata, Kazuma Shinkai, Akira Doi, Kazuyoshi Ohkawa, Masanori Miyazaki, Hisashi Ishida, Kengo Matsumoto, Yasutoshi Nozaki, Takayuki Yakushijin, Ryotaro Sakamori, Takahiro Kodama, Tomohide Tatsumi, and Tetsuo Takehara
Organizer
AASLD 2023
Int'l Joint Research
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[Presentation] Clinical factors associated with the therapeutic efficacy of atezolizumab plus bevacizumab in patients with unresectable hepatocellular carcinoma: A multicenter prospective observational study2023
Author(s)
Kazuki Maesaka, Hayato Hikita, Machiko Kai, Yuki Tahata, Kazuma Shinkai, Akira Doi, Kazuyoshi Ohkawa, Masanori Miyazaki, Hisashi Ishida, Kengo Matsumoto, Yasutoshi Nozaki, Takayuki Yakushijin, Ryotaro Sakamori, Takahiro Kodama, Tomohide Tatsumi, and Tetsuo Takehara
Organizer
APASL Oncology 2023
Int'l Joint Research
