2023 Fiscal Year Research-status Report
Effects of psychological stressors on the pathogenesis of atopic dermatitis
| Project/Area Number |
23K15292
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| Research Institution | Juntendo University |
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Principal Investigator |
趙 巧鳳 順天堂大学, 大学院医学研究科, 博士研究員 (60934601)
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| Project Period (FY) |
2023-04-01 – 2026-03-31
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| Keywords | Stress / Atopic dermatitis |
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| Outline of Annual Research Achievements |
Atopic dermatitis (AD), which is a chronic inflammatory skin disease, manifests as intractable itch. Psychological stress may have a role in the onset or exacerbation of skin disorders such as AD. Psychological stress may influence AD, but the links between psychological stressors and cutaneous manifestations remain unclear.
I have completed the essential techniques for studying Project 1, which include the following steps:
1. Inducing AD-like symptoms; 2. Selecting stressors: Three different types of stressors are selected for stress loading, including WS, RS, and R-SDS; 3. Evaluating the effects of stress on AD symptoms; 4. Studying the effects of stress on alloknesis.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The following research project 1(Generation of AD-like model and evaluation of psychological stress load) was completed last year.
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| Strategy for Future Research Activity |
The following research Project 2:Effects of psychological stress on the structure and function of skin barrier and sensory nerve fibers:
1, [Effects of stress on AD symptoms] The selected stresses will be given from the AD-induced process to NC/Nga mice to evaluate the skin barrier itch behavior and the degree of dermatitis to study the effect of stress on AD pathogenesis.
2, [Effects of stress on sensory nerve fibers] To further confirm the skin barrier disruption and sensory nerve fibers, I will collect and analyze the skin tissues from each group for immunohistochemical and histology.
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| Causes of Carryover |
購入した試薬は、納品期間が長く、3月末には届きませんでした。
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[Presentation] Spinal cholecystokinin-2 receptor is involved in the induction of mechanical alloknesis2023
Author(s)
Tominaga M, Honda K, Kusube F, Tobita T, Komiya E, Yokota M, Kurosawa M, Takahashi N, Toyama S, Zhao Q, Ying Z, Kamata Y, Takamori K.
Organizer
12th World Congress on Itch (WCI), Miami, FL, USA
Int'l Joint Research
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