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2023 Fiscal Year Research-status Report

Zwitterionic Polymers-based Metal Phenolic Networks as Removable Protein Protectants

Research Project

Project/Area Number 23K17211
Research InstitutionJapan Advanced Institute of Science and Technology

Principal Investigator

Rajan Robin  北陸先端科学技術大学院大学, 先端科学技術研究科, 助教 (70848043)

Project Period (FY) 2023-04-01 – 2025-03-31
KeywordsMetal Phenolic Network / Zwitterionic Polymers / Protein Stabilization / Magnetic Separation
Outline of Annual Research Achievements

In the initial phase, I successfully developed and optimized a novel synthetic route for multivalent phenolic poly-sulfobetaine (MPPS), achieving the first-ever synthesis of this unique zwitterionic species. The process involved synthesizing multi-armed alkene and thiol compounds using thiol-ene click chemistry, establishing a robust precursor for further research. This work not only paves the way for groundbreaking applications in protein stabilization but also sets the stage for developing advanced biomaterials aimed at enhancing the stability and transport of therapeutic proteins. The successful synthesis of MPPS signifies a major step toward innovative biomedicine solutions, potentially transforming the storage and handling of protein-based pharmaceuticals.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

The project has progressed smoothly, with significant achievements in developing a novel synthetic route for multivalent phenolic poly-sulfobetaine (MPPS). This effort involved synthesizing multi-armed alkene and thiol compounds via thiol-ene click chemistry, closely aligning with our planned objectives. Despite initial challenges in optimizing reaction conditions, effective adjustments were swiftly implemented, ensuring timely progress. This foundational success sets the stage for further exploration of protein stabilization applications with the synthesized MPPS, positioning us well for future research phases.

Strategy for Future Research Activity

Having applied for the discontinuation of the Kakenhi grant, my focus is on ensuring a thorough conclusion of the research through appropriate channels. This entails overseeing the completion of remaining analyses and the synthesis of results into final reports and publications, to be handled by colleagues in Japan. The project's key accomplishment, the development of a novel synthetic route for multivalent phenolic poly-sulfobetaine (MPPS), will be documented comprehensively. My priority is to ensure that all research findings are meticulously recorded and made available to the scientific community, facilitating further studies in this innovative field.

  • Research Products

    (2 results)

All 2024

All Journal Article (1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Design of Polysulfobetaine Derivatives for Enhanced Inhibition of Protein Aggregation2024

    • Author(s)
      Rajan Robin、Matsumura Kazuaki
    • Journal Title

      Polymer Chemistry

      Volume: NA Pages: NA

    • DOI

      10.1039/D4PY00129J

  • [Presentation] Efficient protein aggregation inhibition with sulfobetaine polymers and their hydrophobic derivatives: molecular mechanisms exploration2024

    • Author(s)
      Robin Rajan, Kazuaki Matsumura
    • Organizer
      European Society of Biomaterials 2023 (ESB2023)
    • Int'l Joint Research

URL: 

Published: 2024-12-25  

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