2023 Fiscal Year Research-status Report
Development of an ultrahigh resolution small animal PET system
| Project/Area Number |
23K17239
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| Research Institution | National Institutes for Quantum Science and Technology |
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Principal Investigator |
KANG HANGYU 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 先進核医学基盤研究部, 主任研究員 (90824467)
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| Project Period (FY) |
2023-04-01 – 2025-03-31
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| Keywords | Small animal PET / In vivo imaging / High-resolution |
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| Outline of Annual Research Achievements |
<Optimization of the crystal and PET geometries>
A Monte Carlo simulation study was performed to find out the optimal crystal geometry in terms of spatial resolution. The optimal crystal geometry has 3-layer staggered depth-of-interaction (DOI) configuration, in which the 1st, 2nd, and 3rd layers have 3 mm, 3 mm, and 5 mm thereby resulting the total thickness of 11 mm. The crystal pitch of 0.8 mm and reflector thickness of 0.1 mm were selected. The optimized PET geometry has an inner diameter of 48 mm, and axial coverage of 23.4 mm.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
<PET geometry optimization>
The crystal and PET geometries were optimized by using the Monte Carlo simulation software in time.The Monte Carlo simulation results were submitted to an international conference, which will be held in the US in 2024.
<Front-end electronics design>
In addition, the signal processing electronics such as front-end boards and amplifier boards were designed, which were originally scheduled on the second fiscal year. The front-end readout boards and amplifier boards were designed by using Altium Designer software. The developed front-end and amplifier boards were working properly.
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| Strategy for Future Research Activity |
<Optimization of a detector>
We plan to optimize the front-end and amplifier boards to improve the detector performance in terms of energy resolution and timing resolution.
<Develop a prototype PET scanner>
We plan to develop a prototype full-ring PET system with the optimized front-end electronics.The performance of the full-ring PET system will be evaluated with the NEMA-NU4 protocol and resolution phantom imaging.
In addition, we plan to perform in vivo mouse brain imaging with the developed PET scanner.
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| Causes of Carryover |
The crystals were not purchased due to the internal budget usage deadline of QST.
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