2023 Fiscal Year Research-status Report
Poly(2-oxazoline)-based pseudo-peptido-coating to improve the long-term biocompatibility of medical devices
| Project/Area Number |
23K19220
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| Research Institution | Kyushu University |
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Principal Investigator |
WEN PANYUE 九州大学, 先導物質化学研究所, 学術研究員 (00976623)
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| Project Period (FY) |
2023-08-31 – 2025-03-31
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| Keywords | poly(2-oxazoline) / medical devices |
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| Outline of Annual Research Achievements |
We successfully prepared a new poly(2-oxazoline), poly(2-ethoxycarbonylethyl-2-oxazoline) and applied coating to several common substrate materials of medical devices including PMMA, PP, PS, PC, and PET. The small contact angle clearly indicates that our new poly(2-oxazoline) coating is more hydrophilic than PMEA coating [~25° for poly(2-oxazoline) vs ~45° for PMEA].
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The Institute for Materials Chemistry and Engineering (IMCE) is an international research institute at Kyushu University promoting research related to the basic science and application of the structure and functions of materials from an atomic, molecular, to supramolecular scale. Particularly, the PI is now working in Prof. Masaru Tanaka Lab. Prof. Tanaka is an expert in the field of biocompatible materials and will provide advisory suggestions for this research. The multidisciplinary and international research team is organized in IMCE.These advanced facilities and multidisciplinary and international team would lay a solid foundation to achieve the research goal.
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| Strategy for Future Research Activity |
The applicant already synthesized one poly(2-oxazoline) and confirmed it can be solubilized in ethanol, allowing methanol-free operation. These preliminary results show that the proposed pseudo-peptido-coating is promising to serve as biocompatible coating for medical devices. The applicant will further control the structure of poly(2-oxazoline) and study performance in details including long-term efficacy, to find the best candidate of pseudo-peptido-coating.
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| Causes of Carryover |
Evaluation of long-term anti-thrombogenic and anti-fouling effect and cell adhesion experiment (such as fibroblast, macrophage, and endothelial cells) need to be performed in detail.
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