Development of a novel organ preservation method applying a hibernation-like state

2024 Fiscal Year Final Research Report

• Project/Area Number: 23K19747
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Kyushu University
• Principal Investigator: Tian Tian 九州大学, 歯学研究院, 助教 (20981260)
• Project Period (FY): 2023-08-31 – 2025-03-31
• Keywords: 歯 / 器官培養 / 低温

Outline of Final Research Achievements

This study investigated cryopreservation methods to acquire preservation techniques for organs in regenerative medicine. Using an organ culture method with mouse tooth germs, we analyzed the effects of culture and preservation under different low-temperature conditions on organ development. The results showed that preservation at 25°C maintained the regeneration capacity of the tooth germs better than at 4°C. This finding suggests that mild hypothermic conditions could be a new preservation strategy for regenerated organs.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

本研究は、再生医療における再生臓器の長期保存という課題に対し、穏やかな低温条件が有効な保存戦略となりうる可能性を示した。25℃における保存が歯胚の再発生能力を比較的良好に保つという発見は、従来の極低温保存の限界を克服する新たな道を開く可能性がある。これにより、必要な時に高品質な再生臓器を安定供給する体制構築に貢献し、再生医療の臨床応用を加速させることが期待される。