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2022 Fiscal Year Annual Research Report

有機エレクトロクロミック物質の新展開:近赤外光スイッチによるバイオイメージング

Research Project

Project/Area Number 20H02719
Allocation TypeSingle-year Grants
Research InstitutionHokkaido University

Principal Investigator

鈴木 孝紀  北海道大学, 理学研究院, 教授 (70202132)

Co-Investigator(Kenkyū-buntansha) 石垣 侑祐  北海道大学, 理学研究院, 准教授 (60776475)
Project Period (FY) 2020-04-01 – 2025-03-31
Keywords動的酸化還元系 / 近赤外色素 / エレクトロクロミズム / バイオイメージング
Outline of Annual Research Achievements

研究計画に沿った研究実験を実施し、その実績について"An Activatable Afterglow/MRI Bimodal Nanoprobe with Fast Response to H2S for In Vivo Imaging of Acute Hepatitis." W. Zeng, L. Wu, Y. Ishigaki, T. Harimoto, Y. Hu, Y. Sun, Y. Wang, T. Suzuki, H.-Y. Chen, D. Ye, Angew. Chem. Int. Ed. 2022, 61, e202111759. [DOI: 10.1002/anie.202111759] および、"A Ratiometric Photoacoustic Probe with a Reversible Response to Hydrogen Sulfide and Hydroxyl Radicals for Dynamic Imaging of Liver Inflammation." L. Wu, W. Zeng, Y. Ishigaki, J. Zhang, H. Bai, T. Harimoto, T. Suzuki, D. Ye, Angew. Chem. Int. Ed. 2022, 61, e202209248. [DOI: 10.1002/anie.202209248]の論文で発表した。上記は、それぞれ、NIR発光の定量性をMRIシグナルで標準化することに成功したバイオイメージングについて、また、NIR発光を2SとOHラジカルの双方のバイオイメージングに成功した例について述べたものである。

新規材料開発についても、"Near-Infrared Electrochromic Behavior of Dibenzothiepin Derivatives Attached by Two Michler's Hydrol Blue Units." Y. Ishigaki, M. Takata, T. Shimajiri, L. Wu, W. Zeng, D. Ye, T. Suzuki, Chem. Eur. J. 2022, 28, e202202457. [DOI: 10.1002/chem.202202457]"で発表するなどの成果も得られている。上記は、ヘキサアリールブタジエン骨格をチエピン、オキセピン骨格に組み込んだ色素を与えるものである。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

昨年度に引き続き、インパクトファクターの高い論文誌(Angew. Chem.)に複数の研究成果を発表することができた。

Strategy for Future Research Activity

研究計画に沿った研究実験を実施により、順調に成果が得られ、また、その公表も進んでいることから、推進方策については変更せずに実施予定である。

  • Research Products

    (10 results)

All 2022 Other

All Int'l Joint Research (2 results) Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 2 results)

  • [Int'l Joint Research] 南京大学(中国)

    • Country Name
      CHINA
    • Counterpart Institution
      南京大学
  • [Int'l Joint Research] ストラスブール大学(フランス)

    • Country Name
      FRANCE
    • Counterpart Institution
      ストラスブール大学
  • [Journal Article] An Activatable Afterglow/MRI Bimodal Nanoprobe with Fast Response to H2S for In Vivo Imaging of Acute Hepatitis2022

    • Author(s)
      Zeng Wenhui、Wu Luyan、Ishigaki Yusuke、Harimoto Takashi、Hu Yuxuan、Sun Yidan、Wang Yuqi、Suzuki Takanori、Chen Hong‐Yuan、Ye Deju
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 61 Pages: -

    • DOI

      10.1002/anie.202111759

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Anthraquinodimethane Ring-Flip in Sterically Congested Alkenes: Isolation of Isomer and Elucidation of Intermediate through Experimental and Theoretical Approach2022

    • Author(s)
      Ishigaki Yusuke、Tadokoro Tomoki、Harabuchi Yu、Hayashi Yuki、Maeda Satoshi、Suzuki Takanori
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 95 Pages: 38~46

    • DOI

      10.1246/bcsj.20210355

    • Peer Reviewed / Open Access
  • [Journal Article] Chalcogen Bond versus Halogen Bond: Changing Contributions in Determining the Crystal Packing of Dihalobenzochalcogenadiazoles2022

    • Author(s)
      Ishigaki Yusuke、Shimomura Kai、Asai Kota、Shimajiri Takuya、Akutagawa Tomoyuki、Fukushima Takanori、Suzuki Takanori
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 95 Pages: 522~531

    • DOI

      10.1246/bcsj.20220008

    • Peer Reviewed / Open Access
  • [Journal Article] Solid‐State Assembly by Chelating Chalcogen Bonding in Quinodimethane Tetraesters Fused with a Chalcogenadiazole2022

    • Author(s)
      Ishigaki Yusuke、Asai Kota、Jacquot de Rouville Henri‐Pierre、Shimajiri Takuya、Hu Johnny、Heitz Valerie、Suzuki Takanori
    • Journal Title

      ChemPlusChem

      Volume: 87 Pages: -

    • DOI

      10.1002/cplu.202200075

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Ratiometric Photoacoustic Probe with a Reversible Response to Hydrogen Sulfide and Hydroxyl Radicals for Dynamic Imaging of Liver Inflammation2022

    • Author(s)
      Wu Luyan、Zeng Wenhui、Ishigaki Yusuke、Zhang Junya、Bai He、Harimoto Takashi、Suzuki Takanori、Ye Deju
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 61 Pages: -

    • DOI

      10.1002/anie.202209248

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multiple molecular interactions between alkyl groups and dissociated bromine atoms on Ag(111)2022

    • Author(s)
      Kawai Shigeki、Sugawara Kazuma、Ma Yujing、Sun Kewei、Custance Oscar、Ishigaki Yusuke、Suzuki Takanori
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 24 Pages: 22191~22197

    • DOI

      10.1039/D2CP03198A

    • Peer Reviewed
  • [Journal Article] Geometrical and Electronic Structure of Cation Radical Species of Tetraarylanthraquinodimethane: An Intermediate for Unique Electrochromic Behavior2022

    • Author(s)
      Ishigaki Yusuke、Fukagawa Reina、Sugawara Kazuma、Harimoto Takashi、Suzuki Takanori
    • Journal Title

      Chemistry - An Asian Journal

      Volume: 17 Pages: -

    • DOI

      10.1002/asia.202200914

    • Peer Reviewed
  • [Journal Article] Near‐Infrared Electrochromic Behavior of Dibenzothiepin Derivatives Attached with Two Michler's Hydrol Blue Units2022

    • Author(s)
      Ishigaki Yusuke、Takata Masaki、Shimajiri Takuya、Wu Luyan、Zeng Wenhui、Ye Deju、Suzuki Takanori
    • Journal Title

      Chemistry - A European Journal

      Volume: 28 Pages: -

    • DOI

      10.1002/chem.202202457

    • Peer Reviewed / Int'l Joint Research

URL: 

Published: 2023-12-25  

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