2021 Fiscal Year Annual Research Report
Needle-free microfluidic vaccine/drug delivery
| Project/Area Number |
21H01253
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| Allocation Type | Single-year Grants |
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| Research Institution | Kumamoto University |
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Principal Investigator |
ホサノ ハミド 熊本大学, 産業ナノマテリアル研究所, 教授 (00543406)
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| Co-Investigator(Kenkyū-buntansha) |
秀 拓一郎 北里大学, 医学部, 准教授 (40421820)
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| Project Period (FY) |
2021-04-01 – 2025-03-31
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| Keywords | ワクチン/ドラッグデリバリー / マイクロフルイディクス / バイオエンジニアリング |
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| Outline of Annual Research Achievements |
The goal of the research for year 2021 (R 3) was defined as theoretical calculation, design, and optimization; construction of the components, experimental models, evaluation; and high-speed microscopic setups.
According to the plan, we performed theoretical calculation to optimize the volume of the vaccine/drug to be delivered with size of the needle-free shock wave injector. Based on the calculations, parts were designed. Design and construction of electrodes, diaphragms, and nozzles for nanosecond-pulsed-electric-field induced cavitation/shock wave streaming micro-injector were performed. Highly magnified shadowgraph and schlieren optical setups with single wavelength bandpass filter and laser as light source for ultra-high-speed visualizations were constructed. The flow physics, plasma, cavitation and microstreaming after nanosecond electric discharge near electrodes were observed. We also constructed a high-speed microscopic setup and performed micro-particle tracking to evaluate speed of the micro-flow filed in skin and tissue/tumor models.
To increase efficiency of the microjet delivery, we took an innovative approach by synthesizing keratin protein nanoparticles for conjugating with the vaccine/drug, which significantly enhances the delivery with minimum amount of the vaccine/drug to reduce the cost.
The obtained results were evaluated for publication.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The research has been progressing according to the plan. The goals for the year 2021 (R 3) have been achieved.
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| Strategy for Future Research Activity |
Based on progress achieved during year 2021 (R 3), measures have been taken for the research to advance as planned. With improvements over the coronavirus restrictions, the research is expected to advance smoothly. Further publication, international conference presentation, and international collaborations have been planned.
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Research Products
(3 results)
