2023 Fiscal Year Annual Research Report
| Project/Area Number |
23H02518
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| Allocation Type | Single-year Grants |
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
REITER Samuel 沖縄科学技術大学院大学, 計算行動神経科学ユ ニット, 准教授 (60869155)
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| Co-Investigator(Kenkyū-buntansha) |
史 蕭逸 筑波大学, 国際統合睡眠医科学研究機構, 助教 (40803656)
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| Project Period (FY) |
2023-04-01 – 2026-03-31
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| Keywords | Sleep / octopus / mice / electrophysiology / computer vision / REM |
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| Outline of Annual Research Achievements |
In FY 2023, we released our first study related to the Kiban B grant. This research focused on the behavioral and neural correlates of two-stage sleep in octopuses, revealing similarities with vertebrate sleep that suggest these aspects may represent convergent features of biological intelligence. Published in the journal Nature, our study attracted coverage in hundreds of news articles globally. We have discussed this study internationally at conferences and seminars, and appeared on television several times explaining our work.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
Our work in the past year has concentrated on physiological recordings from octopus and mice. In octopus, we have recorded active sleep dynamics across different stages of the octopus’ lifecycle, and are currently analyzing the resulting large datasets using computer vision tools. In mice, we have recorded EEG/EMG data from 30-40 mice under various conditions, including drug-dependent increases and decreases in NREM/REM perturbation. We identified several characteristic EEG patterns preceding the down state, an important cortical activity for memory consolidation. These correlations were also confirmed in human EEG data analysis.
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| Strategy for Future Research Activity |
Next year, we will utilize mathematical models to understand the mechanisms and functions of the coupling between the identified EEG patterns and the down state in mouse sleep recordings. We will analyze how octopus active sleep differs across life stages, both in terms of changes in the rhythmic alternation between active and quiet sleep, and in terms of the dynamics of skin pattern change. We will then seek to relate the changes we see across octopus and mice sleep, to look for parallels.
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[Journal Article] Wake-like skin patterning and neural activity during octopus sleep.2023
Author(s)
Pophale A, Shimizu K, Mano T, Iglesias TL, Martin K, Hiroi M, Asada K, Garcia Andaluz G, Dinh THV, Meshulam L, Reiter S
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Journal Title
Nature
Volume: 619
Pages: 129-34
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Wake-like Skin Patterning and Neural Activity During Octopus Sleep.2023
Author(s)
Mano T, Pophale A, Shimizu K, Iglesias T, Martin K, Hiroi M, Asada K, Andaluz PG, Dinh TTV, Meshulam L, Reiter S
Organizer
COSYNE 2023, Montreal, Canada
Int'l Joint Research
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