2023 Fiscal Year Annual Research Report
Development of Reversible Double-Layer Polymer Modification Technology to Break the Safety/Efficacy Trade-Off of Delivering Enzyme
| Project/Area Number |
23H03740
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| Allocation Type | Single-year Grants |
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| Research Institution | Kyushu University |
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Principal Investigator |
LI JUNJIE 九州大学, 先導物質化学研究所, 准教授 (80869892)
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| Co-Investigator(Kenkyū-buntansha) |
田中 賢 九州大学, 先導物質化学研究所, 教授 (00322850)
小林 慎吾 九州大学, 先導物質化学研究所, 特任准教授 (70625110)
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| Project Period (FY) |
2023-04-01 – 2026-03-31
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| Keywords | enzyme delivery / polymer / nanoreactor / oxidation therapy |
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| Outline of Annual Research Achievements |
This proposal aims to develop a simple delivery system for enzyme therapy. This polymer delivery system can synchronize long circulation in blood, precise clearance and degradation by macrophage, and enzyme activation in tumor. Some polymers have been prepared for enzyme delivery. We have tried to encapsulate the enzyme (such as glucose oxidase) and evaluated the cytotoxicity. We have performed some preliminary experiments for in vivo blood circulation and toxicity.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The project progress smoothly.
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| Strategy for Future Research Activity |
We will perform the detailed cell experiments (such as cytotoxicity) and in vivo animal experiments (such as blood circulation, biodistribution, safety, and antitumor effect).
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