Invention of Ion- Fluorescence Multi-Modal Image Sensor System For Elucidation of Cell Functions

2016 Fiscal Year Final Research Report

• Project/Area Number: 24226010
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Electron device/Electronic equipment
• Research Institution: Toyohashi University of Technology
• Principal Investigator: Sawada Kazuaki 豊橋技術科学大学, 工学(系)研究科(研究院), 教授 (40235461)
• Co-Investigator(Renkei-kenkyūsha): SAKURAI Takashi 順天堂大学, 研究企画管理室 (50283362) ; TAKAHASHI Kazuhiro 豊橋技術科学大学, 大学院工学系研究科・電気・電子情報工学系, テニュアトラック講師 (90549346) ; FUTAGAWA Masato 静岡大学, 学術院工学領域・電気電子工学系列, 准教授 (90607871) ; HATTORI Toshiaki 豊橋技術科学大学, 大学院工学系研究科・電気・電子情報工学系, 准教授 (80198762)
• Project Period (FY): 2012-05-31 – 2017-03-31
• Keywords: 集積化バイオセンサ / イメージセンサ / 蛍光 / CMOS / バイオセンサ

Outline of Final Research Achievements

A multi-modal sensor which can detect simultaneously a neurotransmitter, light, and fluorescence on a same pixel was fabricated, and it was applied for bioscience fields. We have realized 45 micron pitch 64x64 pixels ion-fluorescence multimodal sensor which has a same sensor area for ion and fluorescence, and 4 micron pitch 128X128 pixels multimodal image sensor with extended gate structure.Multimodal fluorescence image sensor readout system was also realized to carried out interdisciplinary research with bio scientific researcher. A fluorescence of astrocytes labeled with Calcein-AM taken by the filter-free fluorescence sensor was good agreement with fluorescence intensity observed by conventional fluorescence microscopy.

Free Research Field

工学，電気電子工学，電子デバイス・電子機器