Creation of Transdermal Drug Delivery Systems Using Solid-in-oil Nano-dispersion Technique

2016 Fiscal Year Final Research Report

• Project/Area Number: 24226019
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Biofunction/Bioprocess
• Research Institution: Kyushu University
• Principal Investigator: Goto Masahiro 九州大学, 工学研究院, 教授 (10211921)
• Co-Investigator(Kenkyū-buntansha): 神谷 典穂 九州大学, 工学(系)研究科(研究院), 教授 (50302766) ; 若林 里衣 九州大学, 工学(系)研究科(研究院), 助教 (60595148)
• Co-Investigator(Renkei-kenkyūsha): KUBOTA Fukiko 九州大学, 工学研究院, 助教 (60294899)
• Research Collaborator: KITAOKA Momoko ; TAHARA Yoshiro
• Project Period (FY): 2012-05-31 – 2017-03-31
• Keywords: 経皮ワクチン / DDS / 経皮吸収 / がんワクチン / 花粉症ワクチン / ナノ粒子 / 薬物キャリア / 経皮免疫

Outline of Final Research Achievements

Transdermal drug delivery is receiving a growing concern to alternate conventional drug administration techniques such as oral administration or needle-stick based administration methods. In this project, we proposed a patch system based on a solid-in-oil nanodispersion technique as a simple and efficient delivery method of drugs, especially protein and peptide vaccines, through the skin.
The skin is an attractive route for vaccination, because there are many immune cells. We developed the solid-in-oil nanodisperison technique to deliver pharmaceutical bioactives efficiently through the skin. Solid-in-oil nanodispersions are nanosized drug carriers designed to overcome the skin barrier. Drug administration using a patch is user-friendly, and can improve patient compliance. Protein and peptide antigen drugs were efficiently delivered across the intact skin using the solid-in-oil nanodispersions. The technique is potent transcutaneous immunization method without needles.

Free Research Field

生物化学工学、化学工学、創薬工学