2014 Fiscal Year Final Research Report
Regulatory mechanism of cell cycle progression of neural stem cells
| Project/Area Number |
24240049
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 神経幹細胞 / 細胞周期 / Hes1 / Mash1/Ascl1 / bHLH因子 / プロニューラル因子 / 発現振動 / 光遺伝学 |
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| Outline of Final Research Achievements |
Neural stem cells actively proliferate while giving rise to many cell types. The expression of the bHLH factor Hes1 oscillates with a period of 2-3 hours, and Hes1 oscillation drives the oscillatory expression of the proneural factor Mash1/Ascl1. Mash1/Ascl1 activates the cell cycle progression when its expression oscillates but induces the cell cycle exit and neuronal differentiation when its expression is sustained. Hes1 induces astrocyte differentiation when its expression is sustained. Thus, the oscillatory versus sustained expression of Mash1/Ascl1 and Hes1 regulates the cell cycle progression of neural stem cells.
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| Free Research Field |
分子生物学
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