Multiscale mechanical modeling and analysis of the lung for better understanding of the pathological remodeling mechanism

2015 Fiscal Year Final Research Report

• Project/Area Number: 24240073
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Osaka University
• Principal Investigator: WADA SHIGEO 大阪大学, 基礎工学研究科, 教授 (70240546)
• Co-Investigator(Kenkyū-buntansha): KOSHIYAMA KENICHIRO 大阪大学, 大学院基礎工学研究科, 助教 (80467513) ; II SATOSHI 大阪大学, 大学院基礎工学研究科, 助教 (50513016) ; SERA TOSHIHIRO 九州大学, 工学研究院, 准教授 (40373526) ; MIYAZAKI HIROSHI 藍野大学, 医療保健学部, 教授 (00263228)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: バイオメカニクス / マルチスケール解析 / 肺細葉 / 形態計測 / マイクロCT / リモデリング / 構造解析 / 呼吸音

Outline of Final Research Achievements

Multi-scale mechanical behaviors in the lung such as deformation of the organ, force transmission in the tissue and mechanical response to stretch of cell membrane have been elucidated by computational analyses using a mathematical model for inhomogeneous micro structure of the lung parenchyma, a mechanocell model consisting of cell membrane, nuclear and cytoskeletons, and a molecular dynamics model of cell membrane as well as experimental measurements of lung acinus cluster with a synchrotron micro CT. The developed computational modeling and analyses provide an innovative platform to investigate how the cell and tissue biologically respond to the mechanical environment in the lung that largely deforms by breathing.

Free Research Field

バイオメカニクス