Interaction of DNA repair epigenetics and Nutrition

2016 Fiscal Year Final Research Report

• Project/Area Number: 24240098
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Nara Women's University
• Principal Investigator: MATSUDA Satoru 奈良女子大学, 生活環境科学系, 教授 (50242110)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Keywords: エピジェネティック解析 / 細胞内シグナル伝達 / ＤＮＡ損傷 / ＤＮＡ修復遺伝子 / 癌細胞

Outline of Final Research Achievements

Because p53 plays an important role in the transcriptional regulation of genes encoding proteins involved in DNA repair and apoptosis, the modification of p53 may appear to be a pivotal determinant of cells fate. During carcinogenic progression, p53 is mutated or deleted in nearly half of all human cancers and fails to function normally. Both PTEN and BRCA1 also regulate the expression of several genes identified as key roles in affecting breast and ovarian cancer risk. They also participate in DNA repair and recombination processes related to maintenance of genomic integrity and control of cell proliferation. Genetic defects in DNA repair and DNA damage response genes often lead to an increase in cancer incidence. The role of defects is also associated with modulation of signaling pathways. Furthermore, mutations or epigenetic silencing in DNA repair genes have been associated with a phenotype of sensitivity of cancers to the therapy.

Free Research Field

分子食医化学