Development of new imaging probes for medical use by radioactive isotopes produced with cyclotron beam

2015 Fiscal Year Final Research Report

• Project/Area Number: 24241030
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Quantum beam science
• Research Institution: Osaka University
• Principal Investigator: Shinohara Atsushi 大阪大学, 理学(系)研究科(研究院), 教授 (60183050)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Naruto 大阪大学, 大学院理学研究科, 講師 (00197162) ; KASANATSU Yoshitaka 大阪大学, 大学院理学研究科, 助教 (70435593) ; YOSHIMURA Takashi 大阪大学, ラジオアイソトープ総合センター, 教授 (90323336) ; NINOMIYA Kazuhiko 大阪大学, 大学院理学研究科, 助教 (90512905)
• Co-Investigator(Renkei-kenkyūsha): HATANAKA Kichiji 大阪大学, 核物理研究センター, 教授 (50144530) ; HATAZAWA Jun 大阪大学, 大学院医学系研究科, 教授 (70198745) ; KANAI Yasukazu 大阪大学, 大学院医学系研究科, 助教 (60397643)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 医療用放射性核種 / 分子イメージング / サイクロトロン / 核医学 / PET / RI内用療法 / アスタチン / テクネチウム

Outline of Final Research Achievements

The stable supply of the radioactive isotopes (RI) is essential for medicine and basic science that use the RI. However, we have no systematic RI production and supply system in Japan. In this study, we have developed the large scale irradiation apparatus for RI production using cyclotron beam and prepared 124-I, 62-Zn, and 191-Pt as new probe RI for PET and SPECT. These RI will take an important role for early diagnostics and therapy for cancer, drug development, as well as basic research of medicine and pharmacy. We also recently focus on development of targeted alpha therapy using 211-At, especially, for treatment for recalcitrant tumor. Furthermore we have developed purification method for 99m-Tc produced by an accelerator to confirm the domestic supply system for 99m-Tc.

Free Research Field

放射化学・核化学