Surface Assisted Laser Desorption Ionization Mass Analysis System for Drugs and Toxic Molecules

2015 Fiscal Year Final Research Report

• Project/Area Number: 24241041
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: Hokkaido University
• Principal Investigator: Yonezawa Tetsu 北海道大学, 工学(系)研究科(研究院), 教授 (90284538)
• Co-Investigator(Kenkyū-buntansha): FUJINO Tatsuya 首都大学東京, 准教授 (20360638)
• Co-Investigator(Renkei-kenkyūsha): ISHIDA Yohei 北海道大学, 大学院工学研究院, 助教 (00726713)
• Project Period (FY): 2012-10-31 – 2016-03-31
• Keywords: ナノ粒子 / 金属酸化物 / 質量分析 / レーザー脱離イオン化 / 表面 / イオン化 / ナトリウム / 脱離

Outline of Final Research Achievements

The aims of this study are to prepare suitable nanoparticles for surface-assisted desorption ionization mass spectroscopy and to understand the ionization mechanism by laser irradiation. Lager nanoparticles showed better soft-ionization ability. Therefore, milder increasing of the nanoparticle temperature is important for soft ionization. Also, sodium ion doped TiO2 nanoparticles showed a very high SALDI ability. This result strongly suggest that desorption of molecules by laser irradiation is quite effective and increasing of ionization ability of nanoparticles is an important key to obtain higher sensing ability of SALDI-MS systems.

Free Research Field

ナノ材料科学