Hypervalent Iodine-Catalyzed Organic Reactions Directed towards GSC

2015 Fiscal Year Final Research Report

• Project/Area Number: 24245020
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Nagoya University
• Principal Investigator: Ishihara Kazuaki 名古屋大学, 工学(系)研究科(研究院), 教授 (40221759)
• Co-Investigator(Renkei-kenkyūsha): Uyanik Muhammet 名古屋大学, 大学院工学研究科, 助教 (20452188)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 超原子価ヨウ素 / 不斉触媒 / ヨウ素触媒 / 脱芳香族化反応 / 脱水素カップリング / 酸化的カップリング / キノール / 酸化反応

Outline of Final Research Achievements

Hypervalent iodine compounds are very attractive as alternative resources for heavy metal oxidants green & sustainable chemistry. However, iodine is also a rare element resource in halogen elements. Therefore, the catalytic use of iodine sources are much better from a standpoint of element strategy. Thus, we developed several designer iodine catalysts for selective oxidative reactions: (1) chiral quaternary ammonium hypoiodide-catalyzed enantioselective dehydogenative coupling reactions to provide O, and N-heterocycles, (2) chiral iodosoarene-catalyzed enantioselective dearomatizations ti provide spirocyclic sompounds, (3) IBS-catalyzed regioselective oxidation of 2-substituted phenols to 1,2-qinols. In particular, 2-silylmethyl substituent of phenols are effecyive for IBS-catalyzed regioselective oxidation.

Free Research Field

有機合成化学