Development of highly atom-efficient addition reactions with catalytic functionalizations

2014 Fiscal Year Final Research Report

• Project/Area Number: 24245021
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Kyoto University
• Principal Investigator: TSUJI Yasushi 京都大学, 工学(系)研究科(研究院), 教授 (30144330)
• Co-Investigator(Renkei-kenkyūsha): FUJIHARA Tetsuaki 京都大学, 大学院工学研究科, 助教 (30374698)
• Project Period (FY): 2012-05-31 – 2015-03-31
• Keywords: カルボニル化合物 / 遷移金属触媒 / 官能基化 / パラジウム触媒 / 銅触媒 / 高選択的反応

Outline of Final Research Achievements

Highly selective and efficient functionalizations of unsaturated substrates such as alkynes and 1,2-dienes (allenes) have been developed by utilizing acid chlorides, aldehydes, formamides, and carbon dioxides as functionality sources. Unlike former transformations, proper choice of central metals and ligands of the catalyst prevent loss of the functionalities during the catalytic reactions. Further addition of hydrosilanes, silylboranes, and diboranes to the catalytic systems realized reductive, silylative, and borylative functionalizations.

Free Research Field

触媒有機化学