Supramolecular Enantiodifferentiating Photocyclodimerization of 2-Anthracenecarboxylate with Proteins and Protein-Polymer Hybrids as Chiral Reaction Medias

2014 Fiscal Year Final Research Report

• Project/Area Number: 24245044
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Polymer/Textile materials
• Research Institution: Tohoku University
• Principal Investigator: WADA Takehiko 東北大学, 多元物質科学研究所, 教授 (20220957)
• Co-Investigator(Kenkyū-buntansha): YASUYUKI Araki 東北大学, 多元物質科学研究所, 准教授 (80361179) ; SAKAMOTO Seiji 東北大学, 多元物質科学研究所, 助教 (30335228)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 生体高分子 / 血清アルブミン / キラル反応場 / 不斉合成 / 光反応 / 超分子 / 超分子不斉光反応 / PEG

Outline of Final Research Achievements

Increasing attention has recently been directed toward the new methodology of asymmetric photochemistry using various supramolecules as chiral reaction medias. In this project, we have discussed about the novel strategy and recent results of supramolecular asymmetric photochirogenesis (SMAP) with tailor-made biopolymers as chiral reaction medias. We have reported the enantiodifferentiating photocyclodimerization of 2-antharcenecarboxylate (AC) mediated by bovine and human serum albumin (BSA & HSA) as a chiral reaction media to give the [4+4]-cyclodimers with high enantioselectivities of up to 90 % ee. In this project, effects of polyethylene glycol (PEG) modification of BSA and HSA upon in the ground state and in the excited state interaction with AC were discussed. Additionally supramolecular photochirogenesis of AC dimerization with PEG modified BSA and HSA as chiral reaction medias were also discussed.

Free Research Field

機能高分子化学・有機光化学・生物有機化学