An integrative understanding of physiological processes based on the functional analysis of nuclear transport factors, importins

2014 Fiscal Year Final Research Report

• Project/Area Number: 24247036
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: 独立行政法人医薬基盤研究所 (2014); Osaka University (2012-2013)
• Principal Investigator: YONEDA Yoshihiro 独立行政法人医薬基盤研究所, その他部局等, その他 (80191667)
• Co-Investigator(Renkei-kenkyūsha): OKA Masahiro 国立研究開発法人医薬基盤・健康・栄養研究所, 細胞核輸送ダイナミクスプロジェクト, プロジェクトリーダー (40432504) ; YASUHARA Noriko 国立研究開発法人医薬基盤・健康・栄養研究所, 細胞核輸送ダイナミクスプロジェクト, 特任研究員 (90423152)
• Project Period (FY): 2012-05-31 – 2015-03-31
• Keywords: 核―細胞質間輸送 / 核輸送因子 / インポーティン / 細胞核 / 高次生命機能

Outline of Final Research Achievements

In higher eukaryotes, the nucleocytoplasmic transport of proteins is fine-tuned by multiple mechanisms, including the diversification of transport pathway. Here, we examined various physiological phenomena in mammals through the point of view of the nucleocytoplasmic transport mediated by importin α family, which is comprised of multiple subtypes. Our analysis revealed that the nuclear transport mediated by importin α family plays essential roles in fundamental cellular processes such as signal transduction, cell differentiation and aging.

Free Research Field

細胞生物学