2014 Fiscal Year Final Research Report
Investigation of mental disorder-related molecules through brain synapse formation mechanisms
| Project/Area Number |
24249014
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Tomoyuki 富山大学, 大学院医学薬学研究部, 准教授 (90372367)
UEMURA Takeshi 信州大学, 医学部, 准教授 (00372368)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 神経科学 / 脳神経疾患 / 遺伝子 / シナプス / 学習 / 知的障害 / 自閉症 |
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| Outline of Final Research Achievements |
We showed that glutamate receptor GluRδ2 triggers cerebellar synapse formation by clustering four neurexins through trans-synaptic interaction. In the cerebrum, IL1-receptor accessory protein-like 1 (IL1RAPL1) responsible for intellectual disability and autism spectrum disorder induces spine formation of cortical neurons through Mcf2l-RhoA-ROCK signaling. We found that in addition to IL1RAPL1, IL-1RAcP also mediates synapse formation of cortical neurons through interaction with presynaptic PTPδ. Furthermore, by analyzing the structure of crystalized PTPδ-IL1RAPL1 complex, we showed that mini-exon peptides inserted into immunoglobulin-like domains of PTPδ play critical roles in the interaction with IL1RAPL1.
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| Free Research Field |
神経科学
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