Comprehensive understanding of a unique intestinal epithelial M cells specialized for luminal particulate antigen uptake

2014 Fiscal Year Final Research Report

• Project/Area Number: 24249029
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: OHNO Hiroshi 独立行政法人理化学研究所, 統合生命医科学研究センター, グループディレクター (50233226)
• Co-Investigator(Kenkyū-buntansha): KANATA Takashi 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 (20553829) ; NAKATO Gaku 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 特別研究員 (20584535)
• Project Period (FY): 2012-05-31 – 2015-03-31
• Keywords: 粘膜免疫学 / 細胞・組織 / 発生・分化 / 上皮細胞 / M細胞 / シグナル伝達 / 腸内細菌 / 細菌感染

Outline of Final Research Achievements

Analysis of Spi-B KO mice have revealed that RANKL-signaling in immature intestinal epithelial cells induces the expression of Spi-B transcription factor, which is prerequisite for subsequent M-cell differentiation. We have further elucidated that both canonical and non-canonical NFκB pathways downstream of RANKL-RANKL signaling is required for M-cell differentiation.
We have also shown that terminally differentiated M cells are fewer in cecal patches compared to Peyer’s patched, and that this is due to the lower expression of RelB, a molecule of the non-canonical NFκB pathway, in cecal patches than in Peyer’s patches.

Free Research Field

医学