Understandin the pathogenesis of refratory airway diseases for establishing the personalize medicine

2016 Fiscal Year Final Research Report

• Project/Area Number: 24249049
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: Masaharu Nishimura 北海道大学, 医学研究科, 特任教授 (00208224)
• Co-Investigator(Kenkyū-buntansha): 鈴木 雅 北海道大学, 大学病院, 助教 (10374290) ; 今野 哲 北海道大学, 大学病院, 講師 (20399835) ; 長井 桂 北海道大学, 医学(系)研究科(研究院), その他 (40374293) ; 牧田 比呂仁 北海道大学, 医学(系)研究科(研究院), その他 (70533537)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 気管支喘息 / バイオマーカー

Outline of Final Research Achievements

A total of 206 astmatic subjefts (79 mild-to-moderate、127 severe) were enrolled in this study and several blood biomarkers were measured for all subjets. We found the blood periosrin, osteopntin, and CCL18 were signifiantly assoiated with blood/sputum eosinophils, IgE levels, exhaled nitric oxide fraction, and sinus sore in non-smoking subects. However, in smoking subjects, only periostin was assoiated with Th2-realted asthma phenotypes. In addition, only smoking subjects, these three markers were inversely associated with pulmonary functions. We reported these results in Ann Am Thorac Soc 2017. (in press)

Free Research Field

呼吸器内科学