The development of surgical treatment targeting myocardial stiffness in damaged myocardium

2014 Fiscal Year Final Research Report

• Project/Area Number: 24249070
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Osaka University
• Principal Investigator: SAWA Yoshiki 大阪大学, 医学(系)研究科(研究院), 教授 (00243220)
• Co-Investigator(Kenkyū-buntansha): NISHI Hiroyuki 大阪大学, 大学院医学系研究科, 助教 (00529208) ; YOSHIKAWA Yasushi 大阪大学, 大学院医学系研究科, 特任准教授(常勤) (40570594) ; MIYAGAWA Shigeru 大阪大学, 大学院医学系研究科, 特任准教授(常勤) (70544237) ; FUKUSHIMA Sarsuki 大阪大学, 大学院医学系研究科, 助教 (80596867)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 心筋梗塞 / 細胞外マトリックス / リモデリング / プロスタサイクリン

Outline of Final Research Achievements

We implanted autologous myoblast sheets or prostacyclin agonist to animal heart failure model (rat infarction model, DCM canine model) and analyzed serial changes of cardiac performance especially diastolic function and histological modulation. Myoblast sheet ameliorate cardiac fibrosis by the control of several factors such as MMP and TGF-β etc, leading to improvement of cardiac performance especially diastolic function. Prostacyclin impact on IP receptors expressed on endothelial cells and stimulation of this receptor enhance the expression of several cytokines, resulting in improvement of diastolic function by the reduction of fibrosis in DCM or infarction animal model.

Free Research Field

心臓血管外科学