International collaboration toward establishment of reference value database for common use in evidence-based laboratory diagnosis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24256003
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Laboratory medicine
• Research Institution: Yamaguchi University
• Principal Investigator: ICHIHARA Kiyoshi 山口大学, 医学(系)研究科(研究院), 教授 (10144495)
• Co-Investigator(Kenkyū-buntansha): NOJIMA Junzo 山口大学, 大学院医学系研究科, 教授 (30448071) ; SHIMIZU Yoshihisa 山口大学, 大学院医学系研究科, 助教 (80403674)
• Research Collaborator: GUO Jian Beijing Hospital, Dr ; QIU Ling Beijing Union Medical College, Dr ; XIA Liangyu Beijing Union Hospital, Dr ; ROLLE Reynan Univ of San Agustin ; RAJA Elina Hospital Kuala Lumpur, Dr ; ASHAVAID Tester P.D. Hinduja National Hospital Medical Research Center, Dr ; SHAH Swarup P.D. Hinduja National Hospital Medical Research Center, Dr ; YADAV Binod Institute of Medicine Teaching Hospital ; AHMED Firoz International Center for Diarrheal Disease Research, Dr ; KUMKUM Asifa International Center for Diarrheal Disease Research ; HOSSAIN Anowar International Center for Diarrheal Disease Research, Dr ; GHANI Farooq Aga Kahn Univ, Dr ; JAFRI Lena Aga Kahn Univ, Dr ; KHAN Dilshad Armed Force Institute of Pathology, Prof. ; BORAI Anwar King Khalid National Guard Hospital, Dr ; ÖZARDA Yeşim Uludag Univ, Prof. ; EVGINA Svtlana Beckman Coulter Russia, Dr ; RUZHANSKAYA Anna Beckman Coulter Russia, Dr ; BARTH Julian Leeds Infirmary, Dr ; SCHUMANN Gerhard Univ of Hannover, Prof ; SIEKMAN Lothar Bonn Medical Univ, Prof ; KESSLER Anja Bonn Medical Univ, Dr ; NORDESTGAARD Børge Copenhagen Univ, Prof ; ERASMUS Rajiv Univ of Stellenbosch, Prof. ; HOFFMANN Mariza Univ of Stellenbosch, Dr ; SMIT Francoise Cape Peninsula Univ of Technology ; OMUSE Geoffrey Aga Khan Univ Hospital Nairobi, Dr ; ELGADAR Ola Univ Alexandria, Dr ; BAZ Heba Univ Cairo, Dr ; MARCI Joseph Hamilton General Hospital, Dr. ; KLEE George Mayo Clinic, Prof. ; STRASESKI Joely Univ of Utah, Dr ; STANHOPE Kimber Univ of California Davis, Dr ; SCHREIER Laura Univ of Buenos Aires, Prof. ; BUSTOS Daniel N Univ of Buenos Aires, Dr
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 基準範囲 / EBLM / 標準化 / 生理的変動要因 / 多施設共同調査 / 国際臨床化学連合 / パネル血清

Outline of Final Research Achievements

The methodologies for derivation of reference intervals (RIs) of clinical laboratory tests remain controversial. This investigator launched an international collaborative multicenter study on reference values (RVs) as a project of Committee on Reference Intervals and Decision Limits of International Federation of Clinical Chemistry. Its aims are 1) elaboration of internationally sharable protocol for conducting RI study, 2) establishing optimal statistical methods for derivation of RIs, 3) ensuring standardization of derived RIs, and 4) exploration of sources of variation (SV) of RVs. By March 2015, 16 countries from 5 continents collaborated and RIs of 10 countries have been derived so far by new reliable methods. The reference values of each country were gathered and dynamically aligned to each other based on test results of the serum panel measured in common. A variety of SV of RVs have been revealed, which are all relevant for the practice of evidence-based laboratory diagnosis.

Free Research Field

臨床検査診断学