2014 Fiscal Year Final Research Report
Mechanisms of integration and elimination of adult-born olfactory bulb neurons during olfactory behavior and sleep
| Project/Area Number |
24300118
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 嗅球 / 神経新生 / シナプス構造 / 睡眠 / 末梢性入力 / トップダウン性入力 |
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| Outline of Final Research Achievements |
In the olfactory bulb (OB), neurogenesis continues even in adult. We previously found that selection of new OB neurons between survival and death is promoted during food eating and subsequent sleep.
In this project, we have revealed that 1) top-down synaptic inputs from the olfactory cortex to the OB play crucial roles in the cell selection 2) structure of dendritic protrusions of new OB neurons drastically changes during feeding-sleep and 3) the cell selection is also promoted during fear responses of mice depending on the top-down inputs from the olfactory cortex. These observations enabled us to understand the mechanism of new OB neuron selection with regard to the integration of bottom-up sensory inputs from the periphery and top-down inputs from the olfactory cortex, which can occur during various behaviors of animals.
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| Free Research Field |
神経科学
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