2015 Fiscal Year Final Research Report
Strengthening mechanism of neuronal vitality by necdin
| Project/Area Number |
24300134
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Koichi 大阪大学, 蛋白質研究所, 助教 (20546783)
FUJIWARA Kazushiro 大阪大学, 蛋白質研究所, 助教 (80638495)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Haruki 大阪大学, 蛋白質研究所, 教授 (80134485)
MOCHIZUKI Hideki 大阪大学, 医学部, 教授 (90230044)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | Necdin / ニューロン / エネルギー代謝 / 生存能 / ミトコンドリア / 神経変性疾患 |
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| Outline of Final Research Achievements |
Necdin promoted mitochondrial biogenesis via stabilization of transcriptional co-activator PGC-1α in neurons and suppressed their degeneration induced by mitochondrial electron transport chain enzyme complex inhibitors. Necdin gene transfer into the substantia nigra in vivo of adult mice prevented mitochondrial complex I inhibitor-induced degeneration of dopaminergic neurons. These results revealed that necdin promotes mitochondrial biogenesis and function in neurons to strengthen their vitality.
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| Free Research Field |
分子神経細胞生物学
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