2015 Fiscal Year Final Research Report
Regulation of neuronal circuit development and regeneration by lysophospholipids
| Project/Area Number |
24300137
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Kamiguchi Hiroyuki 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (10233933)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 脊髄 / 感覚神経 / 軸索ガイダンス / グリセロリン脂質 / Gタンパク質共役型受容体 |
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| Outline of Final Research Achievements |
Lipids exhibit vast physicochemical diversity and may participate in biological processes inaccessible to protein-based mechanisms. Here we identify lyso-phosphatidyl-β-D-glucoside (LysoPtdGlc), a novel hydrophilic glycerophospholipid that is synthesised and released by radial glia in a patterned spatial distribution. LysoPtdGlc regulates the development of sensory circuits in the vertebrate spinal cord by sorting nociceptive and proprioceptive afferents at a previously unexplained axon segregation checkpoint. The G protein-coupled receptor GPR55 is a high-affinity receptor for LysoPtdGlc, and GPR55 deletion phenocopies LysoPtdGlc loss-of-function in vivo, misdirecting nociceptive axons into proprioceptive zones. This study demonstrates LysoPtdGlc/GPR55 as a crucial mediator of glia-neuron communication for axon spatial patterning and suggests a broader role for lipids in coordinating diverse biological functions.
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| Free Research Field |
神経細胞生物学
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