Resolving mechanism of structural-functional coupling in red nucleus in motor recovery

2015 Fiscal Year Final Research Report

• Project/Area Number: 24300147
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Fusional basic brain science
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Hayashi Takuya 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (50372115)
• Co-Investigator(Kenkyū-buntansha): Noriyuki Higo 国立研究開発法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 主任研究員 (80357839) ; Hirotaka Onoe 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, グループディレクター (80214196)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 脳損傷 / 拡散強調画像 / MRI / 神経突起 / 神経回路

Outline of Final Research Achievements

The mechanism of functional recovery after stroke and brain injury is not well understood. We established non-invasive imaging system for visualizing long-term changes in brain structure and function and performed experiments in animal mode to investigate how the brain gets plastic and reorganizes the functional-structural coupling. We developed a system for high-resolution diffusion-weighted magnetic resonance imaging (dMRI) and pre-processing pipeline for image analysis. The results showed the long-term functional (motor) recovery and associated microstructural changes in several motor-associated areas. These finding may contribute to the development of novel therapy and diagnosis to accelerate functional recovery after brain injury.

Free Research Field

神経科学、神経画像学