Preparation of Smart Biomaterials Using Dynamic Crosslinks and Their Biomedical Applications

2015 Fiscal Year Final Research Report

• Project/Area Number: 24300175
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kansai University
• Principal Investigator: Miyata Takashi 関西大学, 化学生命工学部, 教授 (50239414)
• Co-Investigator(Kenkyū-buntansha): IWASAKI Yasuhiko 関西大学, 化学生命工学部, 教授 (90280990)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: スマートバイオマテリアル / 高分子ゲル / 動的架橋 / 応答材料 / インテリジェント材料 / 刺激応答性 / DDS / センサー材料

Outline of Final Research Achievements

In this study, biomolecularly stimuli-responsive gels, particles and films with molecular complexes as dynamic crosslinks were strategically designed as smart biomaterials for constructing novel medical systems. The hydrogels, particles and films underwent changes in the volume in response to a target biomolecule. We developed self-regulated drug delivery systems (DDS) and diagnostic sensors using the biomolecularly stimuli-responsive gels, particles and films. In addition, photo-responsive polymers with micro-patternable surfaces were synthesized using photo-dimerization moieties as dynamic crosslinks. Photo-irradiation to the photo-responsive polymers through photo-masks resulted in the formation of micropatterns. The micropatterned surfaces were applied to microcontact printing and cell cultures.

Free Research Field

高分子化学