Mechanism behind cardioprotective effect after chronic exercise in heart failure rats.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24300188
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: MORI Nobuyoshi 東北大学, 医学(系)研究科(研究院), 助教 (50463790)
• Co-Investigator(Kenkyū-buntansha): ITO Osamu 東北大学, 医学系研究科, 准教授 (00361072) ; TOTSUNE Kazuhito 東北福祉大学, 総合福祉学部, 教授 (10217515) ; HIROSE Takuo 東北大学, 医学系研究科, 助教 (20599302) ; KOHZUKI Masahiro 東北大学, 医学系研究科, 教授 (70234698)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 心不全 / 運動療法

Outline of Final Research Achievements

Rats underwent left coronary artery ligation to induce CHF and were randomly assigned to sedentary, treadmill exercise or Candesartan-treat groups 4 weeks after myocardial infarction.
Eight weeks later, left ventricular ejection fraction of Candesartan-treated group showed an improvement trend in echocardiography. Lung weight per body weight ratio was reduced in the exercise group. Heart weight per body weight ratio was reduced by Candesartan group. It is being analyzed for changes in vasoactive substances and extracellular matrix proteins.

Free Research Field

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