Triple combination treatment for upper limb hemiparesis after stroke

2015 Fiscal Year Final Research Report

• Project/Area Number: 24300195
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Jikei University School of Medicine
• Principal Investigator: ABO MASAHIRO 東京慈恵会医科大学, 医学部, 教授 (00266587)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 脳卒中後遺症 / 上肢麻痺 / ボツリヌス毒素 / 反復性経頭蓋磁気刺激 / 集中的リハビリテーション

Outline of Final Research Achievements

A total of 1725 post-stroke patients were studied. The scheduled 15-day protocol was completed by all patients. At discharge, the increase in FMA score, shortening in performance time of WMFT, and increase in functional ability scale score of WMFT were significant. Our proposed combination protocol can be a potentially safe and useful therapeutic intervention for upper limb hemiparesis after stroke, although its efficacy should be confirmed in a randomized controlled study. The combination therapy of rehabilitation plus low-frequency rTMS seems to improve motor function in the affected limb, by activating BDNF processing. BDNF and its precursor proBDNF could be potentially suitable biomarkers for poststroke motor recovery.
We have to perform an evaluation of upper limb hemiparesis after stroke and must consider the combination of concentrated rehabilitation, rTMS, and botulin therapies by recovery time to improve upper limb hemiparesis.

Free Research Field

リハビリテーション