Effect of execise on histone modification in the aged-related muscle loss, sarcopenia

2015 Fiscal Year Final Research Report

• Project/Area Number: 24300224
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Juntendo University (2013-2015); Tokai University (2012)
• Principal Investigator: Machida Shuichi 順天堂大学, スポーツ健康科学研究科, 准教授 (40421226)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: エピジェネティクス / 骨格筋幹細胞 / 筋萎縮 / 身体活動

Outline of Final Research Achievements

Sarcopenia is the age-related loss of skeletal muscle mass and strength leading to physical frailty, loss of independent daily living, increased lifestyle-related disease, and high health care costs.　However, the mechanisms of sarcopenia remain unclear. Exercise is well established as the most effective non-pharmacological intervention to prevent sarcopenia. This study examined the effect of physical activity or inactivity on histone modification in the skeletal muscle. Our results suggest that physical activity or inactivity induce epigenetic modification in the skeletal muscle.

Free Research Field

運動生理学