Association between functional alkaline phosphatase gene expression and aging and/or nutritional factors

2015 Fiscal Year Final Research Report

• Project/Area Number: 24300259
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Japan Women's University
• Principal Investigator: Goseki Masae 日本女子大学, 家政学部, 教授 (00170449)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 骨量調節 / アルカリホスファターゼ / 遺伝子発現 / 栄養因子 / 食生活

Outline of Final Research Achievements

Alkaline phosphatase (ALP) hydrolyzes a variety of monophosphate esters, and bone-type ALP is indispensable for bone mineralization. The bone mass may be determined by genetic as well as environmental factors. In this study, we demonstrated the effects of ALP gene expression on associations among aging and nutritional factors. Our data may be useful for the regulation of mineral metabolism, including the phosphate metabolism pathway. Following the research plan, we examined the effects on bone-type ALP and bone metabolism of various nutrients (vitamins and high-fat diet, etc.), and we reported our findings. Moreover, we analyzed the associations among dietary nutrients intakes, bone mass, bone-type ALP, and related genetic polymorphisms, and we published our discoveries.

Free Research Field

総合領域