2015 Fiscal Year Final Research Report
Analysis of molecular mechanism in the maintenance of cancer stem cells in the vascular niche
| Project/Area Number |
24300330
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Keywords | 腫瘍血管新生 |
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| Outline of Final Research Achievements |
In this study, we defined the molecular cues surrounding blood vessels in the tumor and examined the interaction between blood vessels and cancer cells to know malignant progression of tumor. As a consequence, galactose binding lectin-3 (Gal-3) produced from tumor cells induces migration of macrophage from bone marrow into tumor for progression of tumor angiogenesis. Moreover, Tie2, a receptor tyrosine kinase, expressed in endothelial cells makes a soluble form to inhibit angiogenesis resulting in tumor growth suppression.
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| Free Research Field |
分子発生生物学
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