Identification and functional analysis of the gene(s) associated with endcrine therapy for breast cancer.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24300338
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Tumor diagnosis
• Research Institution: National Cancer Center Japan (2013-2014); Sapporo Medical University (2012)
• Principal Investigator: ZEMBUTSU HITOSHI 独立行政法人国立がん研究センター, 研究所, ユニット長 (90372820)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: タモキシフェン / 乳がん / 個別化医療 / 遺伝子機能解析

Outline of Final Research Achievements

We observed strong association between rs10509373 in C10orf11 and clinical outcome of 240 patients treated with tamoxifen through genome-wide association study. To clarify the function of C10orf11, whose function is unknown, we carried out some assays for investigation of gene expression of C10orf11, the effect on cell growth and screening of the interacting protein. We did not observe the expression of this gene in normal human tissues except adrenal gland, nor its effect on the cell growth. However, C10orf11 was suggested to be related to the wnt signaling in breast cancer. Further analysis focusing on the relationship between wnt signaling and estrogen receptor would clarify the mechanism of regulation of sensitivity to tamoxifen.

Free Research Field

ゲノム医学、薬理遺伝学、遺伝医学