Exploring therapeutic target kinases by comprehensive genome analysis of lung adenocarcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24300345
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Clinical oncology
• Research Institution: National Cancer Center Japan
• Principal Investigator: TSUCHIHARA Katsuya 独立行政法人国立がん研究センター, 早期探索臨床研究センター, 分野長 (00415514)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肺がん / ゲノム / キナーゼ / 分子標的薬 / ゲノムスクリーニング

Outline of Final Research Achievements

We conducted a comprehensive genome analysis of 97 cases of lung adenocarcinoma and explore the mutated protein kinases those could be potential therapeutic targets. All the cases harbored one or more altered kinase or related genes involved in cell proliferation. To establish a cell line-based experimental system that represents the diversity of lung adenocarcinoma, comprehensive genome and epigenome data of 26 cell lines were collected and these data are open for public at our database (http://dbtss.hgc.jp/). We found that LC-2/ad cells express the CCDC6-RET fusion gene and a RET-targeting compound, vandetanib exhibited anti-tumor effect. These findings and experiences encouraged us and other researchers to establish a nation-wide lung cancer genome screening platform and to accomplish investigator-initiated clinical trials targeting lung cancers with rare driver mutations/alterations.

Free Research Field

腫瘍治療学