Comprehensive genomic analysis of small cell lung cancer exploring mechanisms of the proliferation and therapeutic targets

2014 Fiscal Year Final Research Report

• Project/Area Number: 24300346
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Clinical oncology
• Research Institution: National Cancer Center Japan
• Principal Investigator: GOTO Koichi 独立行政法人国立がん研究センター, 東病院, 科長 (90435719)
• Co-Investigator(Kenkyū-buntansha): UMEMURA Shigeki 国立がん研究センター, 東病院, 医員 (80623967) ; TSUCHIHARA Katsuya 国立がん研究センター, 早期/探索臨床研究センター, 分野長 (00415514) ; ISHII Genichiro 国立がん研究センター, 東病院・臨床開発センター, ユニット長 (00270869) ; ESUMI Hiroyasu 国立がん研究センター, 東病院, 院長 (70160364)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 小細胞肺がん / 全エクソン解析 / SNPアレイ / 候補遺伝子 / 臨床情報 / 網羅的 / 予後不良 / PI3K/AKT/mTOR経路

Outline of Final Research Achievements

The mechanisms of the proliferation of small cell lung cancer (SCLC) is not well identified. We conducted a comprehensive genomic analysis in both surgical resected and advanced SCLC cases and found a high penetrance of genetic alterations in the PI3K/AKT/mTOR pathway. These alterations were mutually exclusive with alterations in MYC family members which were reported to play a role in SCLC biology. Additionally, PIK3CA silencing induced a decrease in the proliferation of H1048 cells harboring activating mutation in PIK3CA gene. These results suggested the biological importance of PI3K/AKT/mTOR pathway in the proliferation of SCLC.

Free Research Field

呼吸器内科