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2014 Fiscal Year Final Research Report

Identification of genetic determinant for individual radiosensitivity

Research Project

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Project/Area Number 24310043
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionHiroshima University

Principal Investigator

MATSUURA SHINYA  広島大学, 原爆放射線医科学研究所, 教授 (90274133)

Co-Investigator(Kenkyū-buntansha) MIYAMOTO Tatsuo  広島大学, 原爆放射線医科学研究所, 講師 (40452627)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords放射線感受性 / 個人差
Outline of Final Research Achievements

The current system of radiological protection is uniformly established to the public, and it is important for the radiation risk communication to evaluate the individual radiosensitivity. We studied radiation-induced micronucleus formation in peripheral blood lymphocytes from normal individuals, and found that individual differences of radiosensitivity exist in human populations. We also found that cells from the heterozygous carriers for radiation hypersensitive disorders exhibited an increase of micronucleus formation, suggesting that the DNA repair gene variants are indeed involved in individual radiosensitivity.

Free Research Field

放射線生物学

URL: 

Published: 2016-06-03  

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