A study on the involvement of immune dysfunction in chronic arsenic poisoning

2014 Fiscal Year Final Research Report

• Project/Area Number: 24310048
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Tokushima Bunri University
• Principal Investigator: SUMI Daigo 徳島文理大学, 薬学部, 准教授 (30400683)
• Co-Investigator(Renkei-kenkyūsha): HIMENO Seiichiro 徳島文理大学, 薬学部, 教授 (20181117) ; AKAGI Masaaki 徳島文理大学, 薬学部, 教授 (90093658)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ヒ素化合物 / 免疫毒性 / ナチュラルキラー細胞

Outline of Final Research Achievements

In this study, we examined immune toxicological studies showing whether chronic arsenic exposure affects infection and tumor immunity. Exposure of NK-92 cells (human NK cells) to arsenite reduced cytotoxic activity against human leukemia K562 cell. The mechanism underlying the suppression of cytotoxic activity by arsenite were down-regulation of expression of attack factors such as granzyme B, and up-regulation of inhibitory receptors such as KIR2DL3. When it was investigated using Jurkat cells (human T cell) with an increase in IL-8 and TNF-α by chemical stimuli, arsenite stimulated IL-8 production, while inhibited TNF-α production. In addition, it was measured 27 cytokines in blood samples taken from residents in arsenic contaminated areas in Bangladesh. While the number of cytokines in accordance with the state of the arsenic contamination were increased, decreasing cytokines were also detected.

Free Research Field

分子毒性学