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2014 Fiscal Year Final Research Report

Development and applications of high-efficiency gene targeting in human cells

Research Project

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Project/Area Number 24310149
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Applied genomics
Research InstitutionYokohama City University

Principal Investigator

ADACHI NORITAKA  横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授 (30264675)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywordsゲノム改変 / ジーンターゲティング / ランダム挿入
Outline of Final Research Achievements

We have been developing systems that enable rapid production of human cell lines with the use of plasmid-based DNA vectors. In this research project, we have conducted basic studies aimed at developing ultrahigh-efficiency gene-targeting systems, particularly in terms of controlling random integration, a mechanism that acts to reduce the efficiency of gene targeting.

Free Research Field

分子生物学

URL: 

Published: 2016-06-03  

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