Development of the novel determination methodology for absolute configuration without theoretical calculation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24310151
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Hokkaido University
• Principal Investigator: MONDE Kenji 北海道大学, 先端生命科学研究科(研究院), 教授 (40210207)
• Co-Investigator(Kenkyū-buntansha): TANIGUCHI Tohru 北海道大学, 先端生命科学研究院, 助教 (00587123) ; MURAI Yuta 北海道大学, 先端生命科学研究院, 助教 (20707038)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: VCD / 絶対配置 / 励起き子 / キラリティー / カルボニル

Outline of Final Research Achievements

Vibrational circular dichroism (VCD) is a reliable and non-empirical method which can determine absolute configuration. However, ab initio theoretical calculation for its conformational analysis of a target molecule is essential. In this project, a new methodology for determination of absolute configuration without its theoretical calculation has been developed by utilizing a huge bisignate VCD signal caused by their interaction of two IR functional groups such as carbonyl groups in a target molecule.
This novel methodology named as “VCD exciton chirality method” has been applied to a variety of carbohydrates, steroids, complex natural products, acyclic biological active lipids, and poly lactic acid as a polymer, which shows its high applicability.

Free Research Field

複合領域