Control of Bioreaction via Oligomerization and Orientation of Tumor Suppressor Protein p53 Tetramer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24310152
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Hokkaido University
• Principal Investigator: SAKAGUCHI Kazuyasu 北海道大学, 理学(系)研究科(研究院), 教授 (00315053)
• Co-Investigator(Kenkyū-buntansha): IMAGAWA Toshiaki 北海道大学, 大学院理学研究院, 准教授 (20142177) ; CHUMAN Yoshiro 新潟大学, 大学院自然科学系, 准教授 (40372263)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ペプチド / 生物活性 / 多量体化 / 配向化 / ナノマテリアル

Outline of Final Research Achievements

Oligomerization and spatial orientation is a highly effective strategy for control and extension of functions of biomaterials. In this study, we selected biomineralization as a bioreaction and the p53 tetramerization domain structure as a spatial control element. We evaluated the effect of precisely defining the spatial orientation, arrangement and valency of the biomineralization peptide on the produced nanostructures. The results clearly have demonstrated that oligomerization and spatial orientation of biomineralization peptides via the spatial control element can effectively control the formation, structures and functions of metal nanoparticles.

Free Research Field

生物分子化学